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Production of Penicillin V Fig. 2.8 recaptures the biosynthesis of penicillin. In the last step of the pathway phenoxyacetic acid forms an amide with the amino group of 6-APA. Penicillin V can also be formed directly from isopenicillin N by an exchange of the side chain L-αaminoadipic acid with phenoxyacetic acid. Glucose (s) is the limiting substrate. In a long series of metabolic reactions the three precursor metabolites shown on Fig. 2.8 at the entry to the penicillin synthesis pathway are fi
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