"What is glycation, and what does it mean for my skin?" Glycation is a natural process that occurs when excess sugars bind to proteins in the skin, like collagen, and form toxic molecules known as advanced glycation end-products (A.G.E.). A.G.E.s accumulate over time and weaken skin’s proteins – leading to visible wrinkling and loss of firmness. ✨ NEW ✨ A.G.E. Interrupter Advanced is the Skinceuticals solution for next-generation correction, backed by 15 years of glycation expertise. (swipe left