Myc - Wikipedia
The Myc family consists of three related human genes: c-myc (MYC), l-myc (MYCL), and n-myc (MYCN). c-myc (also sometimes referred to as MYC) was the first gene to be discovered in this …
The MYC oncogene — the grand orchestrator of cancer growth and …
MYC has two paralogues: MYCL and MYCN. The initially held view was that MYC is ubiquitously involved in human cancers (both haematological and solid), whereas L-MYC is associated with small …
MYC Gene - GeneCards | MYC Protein | MYC Antibody
Jan 15, 2026 · MYC (MYC Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYC include Burkitt Lymphomaand High-Grade B-Cell Lymphoma Double …
MYC in cancer: from undruggable target to clinical trials
Feb 19, 2025 · This Review provides an overview of the various strategies to inhibit MYC, focusing on the most recently described inhibitors and those that have reached clinical trials.
MYC: Master Regulator of Cell Death and Tumor Progression
Mar 14, 2025 · MYC gene has become one of the most investigated oncogenes for regulating programmed cell death and tumor growth. MYC is a transcription factor that regulates the expression …
MYC: a multipurpose oncogene with prognostic and therapeutic ...
Aug 9, 2021 · In this review, MYC regulation and the mechanisms by which MYC adjusts cellular functions and its implication in hematologic malignancies are summarized. Further, we also discuss …
Demystifying the Druggability of the MYC Family of Oncogenes
Feb 3, 2023 · The MYC family of oncogenes (MYC, MYCN, and MYCL) encodes a basic helix–loop–helix leucine zipper (bHLHLZ) transcriptional regulator that is responsible for moving the …
Disrupting MYC RNA Interactions Promotes Tumor Regression
5 days ago · While MYC is commonly regarded as an oncoprotein that localizes to promoters and drives transcription of protumorigenic gene programs, emerging studies suggest that its role in cancer may …
MYC: there is more to it than cancer - Frontiers
Mar 6, 2024 · MYC is a pleiotropic transcription factor involved in multiple cellular processes. While its mechanism of action and targets are not completely elucidated, it has a fundamental role in cellular …
Targeting MYC: From understanding its biology to drug discovery
Mar 5, 2021 · In this review, we provide an overview of small molecules developed for clinical applications of these strategies, which include stabilization of the MYC guanine quadruplex, inhibition …