Philadelphia Union (15-5-6, first in the Eastern Conference) vs. New York Red Bulls (10-10-6, eighth in the Eastern Conference) ...

Real Salt Lake (9-12-4, 11th in the Western Conference) vs. Charlotte FC (13-11-2, sixth in the Eastern Conference) ...

Seattle Sounders FC (11-6-8, fifth in the Western Conference) vs. Minnesota United FC (12-6-8, fourth in the Western Conference) ...

Los Angeles FC (10-6-7, sixth in the Western Conference) vs. New England Revolution (7-11-7, 10th in the Eastern Conference) ...

Columbus Crew (12-5-8, third in the Eastern Conference) vs. Toronto FC (5-13-7, 11th in the Eastern Conference) ...

Saint Louis City SC (5-14-6, 15th in the Western Conference) vs. Chicago Fire (10-9-6, eighth in the Eastern Conference) ...

FC Cincinnati (15-7-4, second in the Eastern Conference) vs. Portland Timbers (10-8-7, sixth in the Western Conference) ...

Atlanta United FC (4-11-10, 11th in the Eastern Conference) vs. Colorado Rapids (9-11-6, ninth in the Western Conference) ...