The gene editing tools based on CRISPR/Cas9 include CRISPR knockout (CRISPR KO), CRISPR interference (CRISPRi), and CRISPR activation (CRISPRa). The action mechanism of CRISPR/Cas9 in cells in three ...
Mouse embryonic stem cells differentiated into motor neurons after a GFP tag was inserted in frame with the motor-neuron-specific transcription factor HB9, using CRISPR/Cas9 engineering. The Patent ...
CRISPR-Cas9 has been widely adapted for use in transcriptional modulation and epigenetic engineering with deactivated Cas9 (dCas9) systems to enable CRISPR interference (CRISPRi) and CRISPR activation ...
A new CRISPR screen method developed at Scripps Research has the potential to improve studies into the genetic underpinnings of human diseases and disorders. The method was outlined in Cell, in a ...
CREME is a virtual laboratory that allows scientists to simulate specific decreases in gene activity. It offers a powerful new tool for identifying and understanding important parts of the genome. And ...
UC and Broad have been involved in two interferences at the patent office. Interference No. 106,115 was the second interference between UC and Broad over patent rights to CRISPR-Cas9 technology in ...
Viktor Mamontov, Alexander Martynov, Natalia Morozova, Anton Bukatin, Dmitry B. Staroverov, Konstantin A. Lukyanov, Yaroslav Ispolatov, Ekaterina Semenova, Konstantin Severinov Proceedings of the ...
A poorly characterized protein, historically thought to be a chaperon or enzyme, may actually be a key player in prostate cancer. In a systematic CRISPR screen, scientists from Arc Institute, UCSF, ...
Brendan Jones Ph.D., Xianfeng Morgan Xu, Ph.D. The past week was a truly remarkable week for the CRISPR gene editing field. New developments have reshaped both the legal and scientific landscapes for ...
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