Researchers discover a gut-brain-heart axis where the bacterial metabolite IAA regulates hypocretin neurons to control heart stiffness and blood pressure.

Indole, and structures derived from it, are a component of many natural substances, such as the amino acid tryptophan. A new catalytic reaction produces cyclopenta[b]indoles -- frameworks made of ...

A research group at Nagoya University in Japan has successfully developed an ultrafast and simple synthetic method for producing indole derivatives. Their findings are expected to make drug production ...

In vivo studies have shown that indole-3-acetic acid is derived from tryptophan by at least two pathways. Tryptophan may undergo transamination to indolepyruvic acid, which in turn is degraded to ...

Plants produce an astonishing variety of chemical substances. Most of these metabolites are involved in chemical communication and serve to defend against pests, protect against pathogens, and attract ...

Indole, a molecule made up of a six-membered benzene ring fused to a five-membered ring containing nitrogen, forms the core structure of many biologically active compounds. Derivatives of indole, ...

A cost-effective copper-catalyzed reaction enables selective modification at the C5 position of the indole ring, a backbone for pharmaceutical compounds. Indoles, which form the backbone of many ...

Indole, an organic chemical compound that’s found in our gut and contributes to the smell of poop, increases the healthy lifespan of worms, flies, and mice, according to new research. Scientists say ...

A new chemical reaction pioneered by researchers from the University of Toronto (Toronto, ON, Canada) simplifies the production process for indole rings, a basic molecular frameworks commonly used in ...