DNA ligases are ubiquitous enzymes that catalyse the formation of phosphodiester bonds between adjacent 5′‐phosphate and 3′‐hydroxyl termini in double-stranded DNA. The canonical ligation cycle ...
Ubiquitin ligases are pivotal in safeguarding genome integrity by covalently attaching ubiquitin to proteins involved in the detection, signalling and resolution of DNA lesions. Among these, ...
This matches what the scientists expected given that LIG1 K845N slows symptoms of HD in people. It also suggests that the special way that LIG1 K845N checks over and seals up DNA tiles also somehow ...
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