Human DCAF1 is a multidomain protein that plays a critical role in protein homeostasis. Its WDR domain functions as a substrate recruitment module for RING-type CRL4 and HECT family EDVP E3 ubiquitin ...
This review traces the evolution from biological drugs to small molecule cytokine antagonists, drawing on lessons from TNFα and IL-17 as key case studies. It looks ahead to emerging modalities, ...
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