Fifteen years ago, doctors in Europe noticed a remarkable thing happening in people with chronic hepatitis B infections. When ...

Interim results from SIDNEY Phase 2 trial show EO2463 rapidly induced extensive in vivo expansion of B cell target-specific CD8 ...

Writing in Scientific Reports, researchers from the Stiftung Tieraerztliche Hochschule Hannover and collaborators present the design and evaluation of an artificial poly-epitope sequence comprising 20 ...

Importantly, immune checkpoint blockade can partially reverse CD4+ T cell exhaustion, restore effector function, and enhance therapeutic outcomes, highlighting their pivotal role in determining ...

Clonally expanded CD8+ T cells are key drivers of alopecia areata, mediating epithelial cell death and immune infiltration. JAK inhibitors are approved for AA treatment, but recurrence is common, ...

Scientists have uncovered new genetic rules that determine whether the immune system’s “killer” T cells remain powerful long-term defenders or become worn out and ineffective. By building a detailed ...

Kidney damage is a serious complication affecting individuals with lupus, an autoimmune disease where immune B cells malfunction and produce antibodies that attack the body's own cells, tissues, and ...

Capstan Therapeutics scientists demonstrate that lipid nanoparticles can engineer CAR T cells within the body without laboratory cell manufacturing and ex vivo expansion. The method using targeted ...

Abnormal expansion of PD-1+ T lymphocytes may be a sign of lupus nephritis onset in patients with SLE. Elevated PD-1+CD4+ T cells represent an independent risk factor for lupus nephritis (LN) and may ...

Most of these treatments are based on CD8 T lymphocytes, ''killer cells'' able to eliminate diseased cells. A team from the University of Geneva (UNIGE) has explored an alternative approach involving ...