Two separate laboratory breakthroughs have produced RNA molecules that can build copies of themselves or assemble functional structures without any help from proteins or DNA. These results offer the ...

The modulation of RNA splicing by small molecules has emerged as a promising strategy for treating pathogenic infections, human genetic diseases, and cancer; however, the principles by which splicing ...

Life may have begun when RNA molecules began to replicate themselves, and now we’ve finally found an RNA molecule that is very close to being able to do this ...

RNA-based vaccines were the heroes of the COVID-19 pandemic. They set records for the highest-grossing drug launches in history, and their development was recognized in this year’s Nobel Prize in ...

RNA is a central biological macromolecule, now widely harnessed in medicine and nanotechnology. Like proteins, RNA function often depends on its precise three-dimensional structure. A recent study ...

Although the participation of spliceosomes is almost always required for intron removal, a few types of genes have ...

In a new study, Chinese researchers have discovered the previously unrecognized role of alternative splicing of the DOC2A gene in schizophrenia. The research was conducted by scientists led by LI Ming ...

Cancers driven by hiccups in RNA processing can’t hide from our immune system, according to new work published today in Cell. A cross-institutional team Fred Hutch Cancer Center and Memorial Sloan ...

The eukaryotic spliceosome is a multi-megadalton ribonucleoprotein (RNP) complex found in eukaryotic nuclei that catalyzes the removal of introns (non-coding regions) from pre-mRNA and splices exons ...

As nucleic acid–based therapeutics evolve and mature, so too must the analytical tools that are designed to characterize them. New microfluidic capillary electrophoresis (CE) methods that are designed ...