A bitter taste receptor, TAS2R14, has been shown to respond to both extracellular and intracellular signals. Indeed, it can respond to both signals simultaneously. This finding is especially ...

The structure led to a surprising discovery: the drug binds simultaneously at two distinct positions of the receptor: one copy bound at an extracellular site and the other at the intracellular one.

“Tasting Upside-Down - An Unusual Sensing Mechanism was Found in Human Bitter Sensing” A new study revealed that some bitter molecules target their sensor through binding simultaneously at two ...