New research shows how certain orphan noncoding RNA — oncRNA — can be predictable enough to be a ‘bar code’ identifying ...

The Tas protein uses an RNA guide to recognize a specific target DNA sequence. A vast search of natural diversity has led scientists at MIT’s McGovern Institute and the Broad Institute of MIT and ...

The research team demonstrated that the targeted RNA acetylation system, guided by guide RNA that locates specific RNA within cells, can introduce acetylation chemical modifications to desired RNA.

DNA is transcribed into RNA, which is then translated into proteins. This is the central dogma of molecular biology – a mantra taught to every biology undergraduate student to be recalled and expanded ...

Researchers have built a series of CRISPR-based platforms that can switch endogenous genes on and, just as critically, dial the activation level up or down by adjusting a small-molecule dose. The work ...

Now, following up on that success, a large Chinese collaboration has followed up with a description of an improved gene ...

< Photo 1. (From left) Professor Won Do Heo and Jihwan Yu, a Ph.D. Candidate of the Department of Biological Sciences > CRISPR-Cas13, a powerful RNA-targeting technology is gaining increasing ...

Scientists have gained tremendous control over the genome with CRISPR editing systems, that use a guide RNA molecule to ...

CRISPR functions as a programmable genetic memory system derived from bacterial immune defenses against viral infections. Guide RNA allows for rapid multiplexed targeting compared to older ...

In modern functional genomics, understanding how specific genes control cellular behavior requires both targeted intervention and high-resolution analysis. That’s where Perturb-Seq comes in—a method ...