Formation of fusion proteins. New genes are formed of two originally independent genes by chromosomal rearrangements, including translocations, insertions, deletions, duplications, and inversions.

Access to and Timeliness of Lung Cancer Surgery, Radiation Therapy, and Systemic Therapy in New Zealand: A Universal Health Care Context Gene fusions are critical oncogenic mutations that drive cancer ...

Fusion genes, arising from abnormal chromosomal rearrangements, are gaining recognition as pivotal players in cancer development. These genetic alterations result in the creation of hybrid genes with ...

Prevalence and Distribution of Unexpected Actionable Germline Pathogenic Variants Identified on Broad-Based Multigene Panel Testing Among Patients With Cancer The National Cancer Institute-Molecular ...

NTRK gene fusions have been identified as oncogenic drivers in adult and pediatric patients with pan-solid tumors. A fusion ...

A paper published by researchers at Fox Chase Cancer Center highlights the case of a patient who was diagnosed with adenoid cystic carcinoma (ACC) after a molecular panel identified the presence of an ...

Specific genetic fusion patterns in solitary fibrous tumors may help identify which patients face a higher risk of metastasis, recurrence and more aggressive disease behavior, according to new ...

Weizmann Institute team says blocking a cortisol-driven survival pathway could help overcome resistance to standard hormone therapy.

A drug called selpercatinib cut the risk of early-stage lung cancer coming back by 83% in patients who carry a specific gene.