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Phase I Study of Paclitaxel Given by Seven-Week Continuous Infusion Concurrent With Radiation Therapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck

PURPOSE: Paclitaxel is one of the most active agents for squamous cell carcinoma of the head and neck (SCCHN) and an in vitro radiosensitizer. The dose-response relationship for paclitaxel may depend ...
Nature

Effect of Insulin with Concurrent Amino Acid Infusion on Protein Metabolism in Rapidly Growing Pubertal Children with Type 1 Diabetes

An association between protein catabolism and diabetes has been known for centuries. The Greek physician Aretaeus the Cappadocian described diabetes as a condition that causes “melting of flesh” into ...
Nature

Blood vessel density correlates with the effects of targeted intra-arterial carboplatin infusion with concurrent radiotherapy for squamous cell carcinomas of the oral cavity ...

Inbred female Japanese white rabbits weighing 3–4 kg were used throughout the experiment. The animals were anaesthetised via the auricular vein using pentobarbital sodium (1 mg kg −1), and then VX2 ...