Model shows the role of intrinsically disordered proteins in biomolecular condensate viscoelasticity
Molecular dynamics simulations yield thermodynamic and time-dependent behavior, elucidating the role of intrinsically ...
In a collaborative effort, co-corresponding author Tanja Mittag, PhD, and co-first author Wade Borcherds, PhD, St. Jude Department of Structural Biology, interrogated the interaction networks within ...
Biomolecular condensates are membraneless hubs of condensed proteins and nucleic acids within cells, which researchers are realizing are tied to an increasing number of cellular processes and diseases ...
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Machine learning reveals how disordered protein regions contribute to cancer-causing condensates
Fusion oncoproteins arise when a gene fuses with another gene and acquires new abilities. Such abilities can include the formation of biomolecular condensates, "droplets" of concentrated proteins, DNA ...
For decades, cancer research has focused on the dysregulation of various cellular pathways, including transcription, chromatin structure, proliferative signaling, RNA processing, and genomic integrity ...
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