Shelton withdrew from his third-round match against Adrian Mannarino because of a shoulder injury. Shelton was the No. 6 seed in the men's singles draw but struggled with the shoulder injury throughout the first four sets before withdrawing ahead of what would have been a decisive fifth.

Ben Shelton’s US Open came to an end in the third round when he was forced to retire against Adrian Mannarino with a shoulder injury.

The American No. 6 seed led Adrian Mannarino of France 2-1 when he hurt his hitting arm shoulder during an intensely physical contest.